PubMedCrossRef 13. Yang LL, Wang MC, Chen LG, Wang CC: Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. Planta Med 2003, 69:1091–5.PubMedCrossRef 14. Chou SY, Hsu CS, Wang KT, Wang MC, Wang CC: Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study. Phytother Res 2007, 21:226–30.PubMedCrossRef
15. Yang D, Gu T, Wang T, Tang Q, Ma C: Effects of osthole on migration and invasion in breast cancer cells. Biosci Biotechnol Biochem 2010, 74:1430–4.PubMedCrossRef 16. Riviere C, Goossens L, Pommery N, Fourneau C, Delelis A, Henichart JP: Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker. Nat Prod Pifithrin-�� molecular weight Res 2006, 20:909–16.PubMedCrossRef 17. Okamoto T, Kobayashi T, Yoshida S: Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas. Curr Med Chem Anticancer Agents 2005, 5:47–51.PubMedCrossRef 18. Kauffmann-Zeh click here A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, Evan G: Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 1997, 385:544–8.PubMedCrossRef 19. Vivanco I, Sawyers CL: The phosphatidylinositol 3-Kinase AKT pathway
in human cancer. Nat Rev Cancer 2002, 2:489–501.PubMedCrossRef 20. Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, Tridandapani S, Anant S, Kuppusamy P: Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther 2007, 6:178–84.PubMedCrossRef 21. Katayama K, Fujita N, Tsuruo T: Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote Ergoloid cell cycle progression at G2/M transition. Mol Cell Biol 2005, 25:5725–37.PubMedCrossRef 22. Asnaghi L, Calastretti A, Bevilacqua A, D’Agnano I, Gatti G, Canti G, Delia D, Capaccioli S, Nicolin A: Bcl-2 phosphorylation and apoptosis activated by damaged
microtubules require mTOR and are regulated by Akt. Oncogene 2004, 23:5781–91.PubMedCrossRef 23. Xavier CP, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, Pereira-Wilson C: Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer Lett 2009, 281:162–70.PubMedCrossRef 24. Pu L, Amoscato AA, Bier ME, Lazo JS: Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione. J Biol Chem 2002, 277:46877–85.PubMedCrossRef 25. Chao JI, Kuo PC, Hsu TS: Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells. J Biol Chem 2004, 279:20267–76.PubMedCrossRef 26. Wang Y, Ji P, Liu J, Broaddus RR, Xue F, Zhang W: Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy. Mol Cancer 2009, 8:8.PubMedCrossRef 27.