Moreover, our data describe a novel miR-196a/ NFKBIA link and imply a potential therapeutic target of miR-196a for pancreatic carcinoma. Key Word(s): 1. miR-196a; 2. pancreatic carcinoma; Sirolimus supplier 3. NFKBIA; Presenting Author: LINJIE GUO Additional Authors: CHUN HUI

WANG, CHENG WEI TANG Corresponding Author: CHENG WEI TANG Affiliations: West China Hospital Objective: The annual incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is still unclear in China. The objective of this study is to estimate the incidence of GEP-NETs in Chengdu city, the fourth biggest city of China. Methods: This study estimated the incidence of GEP-NETs in Chengdu city with the database of West China Hospital and population-based data from Chengdu Health Bureau during 2006 – 2010. Among the hospitals with the ability to diagnose GEP-NETs in Chengdu

city, the annual patients in West China Hospital were 25.6%∼28% of those in whole of the PARP inhibitor hospitals during the past five years. GEP-NETs incidence in Chengdu was yielded by the number of annual new patients with GEP-NETs in West China Hospital divided with the 25.6% ∼ 28% population of Chengdu city. Results: GEP-NETs incidence in Chengdu increased 1.89 folds during past 5 years from 1.13/100000 to 2.14/100000, p < 0.05. The average duration of symptom before diagnosis was 15 months. Application of GI-Endoscopy increased during the five years. About 46.4% of GEP-NETs were later stage when diagnosis was made. 77% patients were over 40 years. Proportions of GEP-NETs from most common primary sites were rectum 30.6%, pancreas 23.4%, gastric 13.3%, esophagus 11.3%. Proportions of insulinoma, vipoma and non-functional pancreatic neuroendocrine tumors (P-NETs) were 43.1%, 1.7% and 55.2% separately in the P-NETs. Conclusion: The incidence of GEP-NETs is

increasing in Chengdu area with a population of 14.04 million. There is a distinct epidemiologic profile for each primary site. The delayed diagnosis Galeterone reflects limited medical education regarding GEP-NETs, inadequate disease awareness and paucity of research funding. Key Word(s): 1. GEP-NETs; 2. Incidence; 3. Chengdu city; 4. China; Presenting Author: YALEI WANG Additional Authors: HUI FENG, WEIYAN YAO, XI CHEN, CHENYU ZHANG Corresponding Author: YALEI WANG Affiliations: The first affiliated hospital of Anhui Medical University; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; School of Life Sciences, Nanjing University Objective: MicroRNAs are endogenous non-coding RNAs, playing an important role in regulating gene expression by blocking the translation or triggering the degradation of the target mRNAs. MicroRNA-148a was described to be down-regulated in several types of solid cancers, while it has not been studied in pancreatic cancer.