It is very important to demonstrate the effectiveness of PV in the separation of actual clostridia fermentation broths, and to identify the factors affecting PV performance. (C) 2011 Society of Chemical Industry”
“Background-Elevated blood pressure (BP) shares a level of heritability similar
to many other traits related to cardiovascular risk; however, specific susceptibility loci have been difficult to localize. We conducted a multistage study of BP as a continuous trait in a low-risk West African GSI-IX population in which it was anticipated that environmental exposures would be reduced in complexity and intensity. In our earlier genome-wide linkage study for BP in this population, strong linkage evidence was noted on chromosomes 6 and 7.
Methods and Results-We subsequently genotyped a total of 3431 tag single-nucleotide polymorphisms (SNPs) in 3 regions (viz, 152.68 to 165.99 Mb on chromosome 6, 0.29 to 20.67 Mb, and 104.09 to 123.06 Mb on chromosome 7) in 713 individuals from 199 families. We conducted a family-based association analysis using individual SNPs and associated haplotypes. After correction for multiple comparisons, 6 intronic and 1 intergenic SNPs achieved nominal statistical significance (P < 0.05) for the association Pictilisib concentration with BP. The associated intronic SNPs include
2 in the PARK2 gene on chromosome 6; 2 in the KCND2 gene, and 1 each in the C7orf58 Metabolism 抑制剂 and HDAC9 genes on chromosome 7. The intergenic SNP is located between the RPA3 and GLCCI1 genes on chromosome 7. The haplotypes on which these SNPs resided were more strongly associated with BP than their respective single SNPs. The frequency
of the “”at-risk”" haplotypes ranged from 14% to 48%.
Conclusions-These data provide preliminary evidence that regions on chromosomes 6 and 7 may influence susceptibility to elevations in BP. (Circ Cardiovasc Genet. 2009;2:38-45.)”
“Seven new isopimarane diterpenoids, orthoarisins A-G (1-7), a new secoisopimarane diterpenoid, orthoarisin H (8), a new staminane diterpenoid, orthoarisin I (9), together with 15 previously reported diterpenoids were isolated from the aerial parts of Orthosiphon aristatus var. aristatus. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 13, 17, and 23 showed weak inhibitory activity on the proliferation of the SKOV3, DU145, and PC-3 cell lines. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.”
“BACKGROUND: The authors (Chem Eng J 148, 234 (2009)) previously demonstrated the excellent performance of a photocatalytic reactor with a parallel array of nine light sources. To enhance the possibility of practical application of this reactor, the present work explores the use of a PET (polyethylene terephthalate) sheet as a new cheap material to support TiO(2), as an alternative to glass tubes.