Four patients (44%) had isolated cutaneous disease, while 5 cases (56%) had systemic LOXO-101 nmr involvement including renal artery microaneurysms (2 patients), cholecystitis (1 patient), mononeuritis multiplex (2 patients), and mesenteric vasculitis (1 patient). Median duration of minocycline use was 2 (range 1 to 4) years. Three patients had a positive antinuclear antibody with negative extractable nuclear antigen antibodies. All patients had positive antineutrophil
cytoplasmic antibody in a perinuclear pattern but specificity to myeloperoxidase was observed in 2 patients (22%). Diagnosis was confirmed by histopathology in 6 patients (67%) and angiography in 3 patients (33%). Minocycline was discontinued in all cases. Further immunosuppressive therapy was added in 6 cases (67%).
Conclusions: Cutaneous, as well as systemic, PAN-like vasculitis may occur in association with minocycline use. Clinicians should consider the possibility of drug-induced vasculitis, especially in cases of medium-vessel vasculitis with atypical antineutrophil cytoplasmic antibody serologies or in patients with negative hepatitis B testing. (C) 2012 Published by Y-27632 in vivo Elsevier Inc. Semin Arthritis Rheum 42:213-221″
“Skin delivery of NSAIDs
offers several advantages over the oral route associated with potential side effects. In the present investigation, topical gel of meloxicam (MLX) was formulated using N-methyl pyrrolidone learn more (NMP) as a solubilizer and Carbopol Ultrez 10 (R) as a gelling polymer. MLX gel was evaluated with respect to different physicochemical parameters such as pH, viscosity and spread-ability. Irritation potential of MLX gel was studied on rabbits. Permeation of MLX gel was studied using freshly excised rat skin as a membrane.
Anti-inflammatory activity of MLX gel was studied in rats and compared with the commercial formulation of piroxicam (Pirox (R) gel, 0.5% m/m). Accelerated stability studies were carried out for MLX gel for 6 months according to ICH guidelines. MLX gel was devoid of any skin irritation in rabbits. After 12 h, cumulative permeation of MLX through excised rat skin was 3.0 +/- 1.2 mg cm(-2) with the corresponding flux value of 0.24 +/- 0.09 mg cm(-2) h(-1). MLX gel exhibited significantly higher anti-inflammatory activity in rats compared to Pirox (R) gel. Physicochemically stable and non-irritant MLX gel was formulated which could deliver significant amounts of active substance across the skin in vitro and in vivo to elicit the anti-inflammatory activity.”
“Purpose of review
Lung transplantation can improve survival and quality of life in select patients with end-stage lung disease. Because of the limited availability of donor lungs and limited post-transplant survival of recipients, selection of candidates that are most likely to benefit from transplantation is of utmost importance.