In March 2005, the Remission in Schizophrenia Working Group (RSWG)1 published a consensus definition of remission in schizophrenia, and developed operational criteria for its assessment (henceforth called the RSWG criteria). These criteria define remission as a level of core schizophrenia symptoms that does not interfere with an individual’s behavior and is below that required for a diagnosis of schizophrenia to be made according to the Diagnostic and

Statistical Manual of Mental Disorders (DSM-IV). The criteria consist of two elements: • A scientific assays symptom-based criterion, which includes seven diagnostically relevant items from the DSM-IV. The seven items specified in the DSM criteria were then cross-matched to three different rating scales #selleck chem Bosutinib keyword# (Positive and Negative Syndrome Scale [PANSS], the Scale for the assessment of negative symptoms and positive symptoms [SANS/SAPS], and the Brief Psychiatric Rating Scale [BPRS]). They correspond to eight items in the PANSS, all of which have to be scored with a symptom severity of ≤3 points (“mild” Inhibitors,research,lifescience,medical or better). The eight symptoms include: (i) delusions; (ii) unusual thought content; (iii) hallucinatory behavior; (iv) conceptual disorganization; (v) mannerisms/posturing;

(vi) blunted affect; (vii) passive/apathetic social withdrawal; (viii) lack of spontaneity and flow of conversation Inhibitors,research,lifescience,medical (Table I). The symptom-based criterion can also be assessed using the SANS/SAPS (severity ≤2 points). The BPRS (severity ≤3 points) does not contain adequate representation of negative symptoms and is therefore alone not satisfactory for evaluating Inhibitors,research,lifescience,medical remission. The two negative symptoms not included in the BPRS

(ie, “social withdrawal” and “lack of spontaneity”) need to be additionally assessed with PANSS or SANS when BPRS is used. Table I. Inhibitors,research,lifescience,medical Proposed items for remission criteria of psychopathology dimensions and DSM-IV and ICD-10 criteria for schizophrenia. • A time criterion, which requires that an individual achieves the symptom-based criteria for a minimum of 6 months.1 According to the RSWG, these criteria represent an absolute threshold rather than a relative improvement from a predefined baseline, which can be applied to patients at all stages of the disease and that may facilitate cross-trial comparisons of interventions.1-4 The corresponding European Working group concluded Entinostat that this definition will enhance the conduct of clinical investigations and reset expectations for treatment outcome at a higher level.5 It is further essential to point out that the remission criteria can be applied only to patients who have previously been diagnosed using recognized diagnostic criteria and that fulfilling the remission criteria does not mean that the diagnosis is no longer applicable.5 Finally, the application of the criteria does not imply or depend on any preconceptions about the causal mechanisms underlying the illness, or those that may have brought about remission.