914). The mean LSMs values (kPa) were significantly higher in patients with liver cirrhosis diagnosed by means of biological, clinical, ultrasonographic and/or endoscopic criteria as compared with those diagnosed by LB: 32.8±19.7 (median 28.8 kPa) vs. 18.4±8.8 (median 15.9), p<0.0001. Conclusion: TE is a useful method for non-invasive liver fibrosis evaluation in subjects chronically infected with HBV. Key Word(s): 1. liver fibrosis; 2. liver stiffness; 3. FibroScan; 4. HBV; Presenting Author: IOAN SPOREA Additional Authors: ROXANA SIRLI, SIMONA BOTA, ALEXANDRA DELEANU, ISABEL DAN, ALINA POPESCU, ANA JURCHIS, MELENIA ARDELEAN, NADIA CORNU, MIRELA DANILA Corresponding
Author: IOAN SPOREA Affiliations: Department of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Romania Objective: to evaluate the usefulness of Transient Elastography www.selleckchem.com/products/INCB18424.html (TE) for the evaluation of subjects chronically infected with hepatitis C virus (HCV). Methods: Our study included 788 succesive patients chronically infected with HCV evaluated in our Department between June 2007-December 2012 (473 patients with chronic MG132 hepatitis C evaluated by liver biopsy – LB, and 315 patients with liver cirrhosis diagnosed by means of biological, clinical, ultrasonographic and/or endoscopic criteria, in whom we excluded the presence
of ascites). In each patient we performed liver stiffness measurements (LSMs) by using a FibroScan device (Echosens, Paris, France). Ten valid LSMs were performed in each patient, by using the standard M-probe; a median
value was calculated and expressed in kiloPascals (kPa). TE measurements were considered reliable if 10 valid measurements could be acquired with at least 60% success rate and less than 30% interquartile range interval. Results: Reliable LSM measurements were obtained in 84.2% of patients. Mannose-binding protein-associated serine protease The rate of reliable measurements was significantly higher in chronic hepatitis patients (with LB) as compared with cirrhotic patients: 95.9% vs. 66.7%, p<0.0001. In patients with LB, the mean LSMs values (kPa) according to the different stages of fibrosis were: F0-5.2±0.7 (median 4.9), F1-5.6±1.8 (median 5.4), F2-6.7±2.5 (median 6.3), F3-10.1±4.9 (median 8.8) and F4-18.1±5.5 (median 17.1). The best TE cut-offs for predicting various stages of liver fibrosis were: F≥1-6.4 kPa (AUROC=0.783), F≥2 – 6.8 kPa (AUROC=0.751), F≥3 – 7.7 kPa (AUROC=0.810), F=4-12.6 kPa (AUROC=0.954). The mean LSMs values (kPa) were significantly higher in patients with liver cirrhosis diagnosed by means of biological, clinical, ultrasonographic and/or endoscopic criteria as compared with those diagnosed by LB: 31.6±17.8 (median 26.3 kPa) vs. 18.1±5.5 (median 17.1), p<0.0001. Conclusion: TE is a useful method for non-invasive liver fibrosis evaluation in subjects chronically infected with HCV. Key Word(s): 1. liver fibrosis; 2. liver stiffness; 3. FibroScan; 4.