914) The mean LSMs values (kPa) were significantly higher in pat

914). The mean LSMs values (kPa) were significantly higher in patients with liver cirrhosis diagnosed by means of biological, clinical, ultrasonographic and/or endoscopic criteria as compared with those diagnosed by LB: 32.8±19.7 (median 28.8 kPa) vs. 18.4±8.8 (median 15.9), p<0.0001. Conclusion: TE is a useful method for non-invasive liver fibrosis evaluation in subjects chronically infected with HBV. Key Word(s): 1. liver fibrosis; 2. liver stiffness; 3. FibroScan; 4. HBV; Presenting Author: IOAN SPOREA Additional Authors: ROXANA SIRLI, SIMONA BOTA, ALEXANDRA DELEANU, ISABEL DAN, ALINA POPESCU, ANA JURCHIS, MELENIA ARDELEAN, NADIA CORNU, MIRELA DANILA Corresponding

Author: IOAN SPOREA Affiliations: Department of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Romania Objective: to evaluate the usefulness of Transient Elastography www.selleckchem.com/products/INCB18424.html (TE) for the evaluation of subjects chronically infected with hepatitis C virus (HCV). Methods: Our study included 788 succesive patients chronically infected with HCV evaluated in our Department between June 2007-December 2012 (473 patients with chronic MG132 hepatitis C evaluated by liver biopsy – LB, and 315 patients with liver cirrhosis diagnosed by means of biological, clinical, ultrasonographic and/or endoscopic criteria, in whom we excluded the presence

of ascites). In each patient we performed liver stiffness measurements (LSMs) by using a FibroScan device (Echosens, Paris, France). Ten valid LSMs were performed in each patient, by using the standard M-probe; a median

value was calculated and expressed in kiloPascals (kPa). TE measurements were considered reliable if 10 valid measurements could be acquired with at least 60% success rate and less than 30% interquartile range interval. Results: Reliable LSM measurements were obtained in 84.2% of patients. Mannose-binding protein-associated serine protease The rate of reliable measurements was significantly higher in chronic hepatitis patients (with LB) as compared with cirrhotic patients: 95.9% vs. 66.7%, p<0.0001. In patients with LB, the mean LSMs values (kPa) according to the different stages of fibrosis were: F0-5.2±0.7 (median 4.9), F1-5.6±1.8 (median 5.4), F2-6.7±2.5 (median 6.3), F3-10.1±4.9 (median 8.8) and F4-18.1±5.5 (median 17.1). The best TE cut-offs for predicting various stages of liver fibrosis were: F≥1-6.4 kPa (AUROC=0.783), F≥2 – 6.8 kPa (AUROC=0.751), F≥3 – 7.7 kPa (AUROC=0.810), F=4-12.6 kPa (AUROC=0.954). The mean LSMs values (kPa) were significantly higher in patients with liver cirrhosis diagnosed by means of biological, clinical, ultrasonographic and/or endoscopic criteria as compared with those diagnosed by LB: 31.6±17.8 (median 26.3 kPa) vs. 18.1±5.5 (median 17.1), p<0.0001. Conclusion: TE is a useful method for non-invasive liver fibrosis evaluation in subjects chronically infected with HCV. Key Word(s): 1. liver fibrosis; 2. liver stiffness; 3. FibroScan; 4.

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