Two of 13 perigastric lymph nodes were positive for metastatic disease, composed of only the squamous component. Figure 2. CT scan showed a 10 cm x 10 cm multi-lobulated mass (arrow) located within the gastric lumen which was inseparable from the tail of the pancreas. Several foci of central necrosis were observed within the Inhibitors,research,lifescience,medical mass. Figure 3 (A). Adenosquamous carcinoma composed of malignant squamous elements (arrow) and glandular elements (two arrows); (B). Lymph node with

metastatic malignant squamous carcinoma. The patient had an uneventful post-operative course and was discharged home on post-operative day 17. He remains well one month after surgery and has been referred to radiation and medical oncology. After he sufficiently recovers from surgery, consideration will

be made to pursue potentially curative resection versus chemoradiation or palliative treatment. Discussion Adenosquamous carcinoma of the pancreas, also referred to as “adenocanthoma” and “mucoepidermoid carcinoma” (1),(2) is a rare entity, Inhibitors,research,lifescience,medical representing only 1-4% of all known pancreatic malignancies (3)-(5). Similar to adenocarcinoma, the most common symptoms associated with ASC are weight loss, anorexia, malaise, abdominal pain, fatigue and nausea. These tumors possess components of both glandular and malignant squamous cell origins, Inhibitors,research,lifescience,medical which should both be present to ensure proper diagnosis. Diagnosis of ASC is challenging and frequently not made until the time of surgery or during post-mortem examination. The use of ultrasound-guided FNA or ERCP-guided aspiration for making a pre-operative diagnosis remains controversial. No imaging criteria are specific to ASC, Inhibitors,research,lifescience,medical causing most of these tumors to be mistaken for ductal adenocarcinoma of the pancreas when initially imaged.

However, CT findings of large pancreatic lesions with infiltration of surrounding tissues and central necrosis have been reported and should raise one’s suspicion for ASC (6). Widely disseminated disease is commonly present at the Inhibitors,research,lifescience,medical time of initial presentation. AG-1478 datasheet Although diffuse disease usually prevents resection, palliative surgery may still be indicated in cases of hemorrhage, perforation or obstruction. Even when potentially curative surgical resection is performed, prognosis is generally regarded as extremely poor. In 2008, Okabayashi et al reviewed 39 cases first of ASC treated with pancreatic resection (pancreaticodudenectomy, distal pancreatectomy or total pancreatectomy) spanning 1980 through 2007 (7). In this review, the 1-year and 3-year survival rates following pancreatic resection were 25% and 14%. Nevertheless, some reports have demonstrated a survival benefit for patients undergoing an R0 resection (8). Similarly, Voong et al showed a survival benefit for patients treated with adjuvant chemoradiation therapy (4).