The purpose of this study was to evaluate the changes in maternal serum IGF-I during pregnancy and their relationship to maternal anthropometry, including body weight (BW) and body mass index (BMI).
Methods: We obtained 332 blood samples from Doramapimod datasheet 114 expectant mothers at different gestational ages (Gas) without adverse medical history. Serum IGF-I levels were measured by immunoradiometric assay. Linear regression analysis for continuous variables and t test for comparisons of categorical variables were used to test for significance.
Results: Maternal serum IGF-I during pregnancy was significantly correlated not only to GA (p <0.001,
r = 0.358), but also to maternal BW (p = 0.001, r = 0.202), and maternal BMI (p < 0.001, r = 0.263). The mean maternal IGF-I was highest in the third trimester [1st vs.
2nd, p < 0.001, 95% confidence interval (CI) = 70.17 to 28.22; 1st vs. 3rd, p < 0.001, 95% CI = 138.02 to 76.94; 1st vs. 3rd, p < 0.001, 95% CI = 88.86 to 27.71].
Conclusion: Maternal serum IGF-I is significantly related to GA, maternal BW, and BMI during pregnancy. Copyright (C) 2013 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.”
“Consumption of flavanols improves chronic endothelial dysfunction. We investigated whether it can also improve acute lipemia-induced endothelial dysfunction. In this MK 8931 randomized, placebo-controlled, double-blind, crossover trial, 18 healthy subjects received a fatty meal with cocoa either rich in flavanols (918 mg) or flavanol-poor. Flow-mediated dilation (FMD), Sotrastaurin mouse triglycerides, and free fatty acids were then determined over 6 h. After the flavanol-poor fat loading, the FMD deteriorated over 4 h. The consumption of flavanol-rich cocoa, in contrast, improved this deterioration in hours 2, 3, and 4 without abolishing it completely. Flavanols
did not have any influence on triglycerides or on free fatty acids. Flavanol-rich cocoa can alleviate the lipemia-induced endothelial dysfunction, probably through an improvement in endothelial NO synthase.”
“Employment is an indicator of socioeconomic status. Unemployment is a worldwide social challenge, especially in emerging countries, accounting for a proportion of the overall higher mortality rates found in these nations. We assessed the relationship between employment status and in-hospital mortality among acute ischemic stroke patients participating in the Argentinean National Stroke Registry (ReNACer), a prospective, country-wide, hospital-based stroke registry aimed at improving quality of stroke care in Argentina. We compared demographic and socioeconomic characteristics, risk factors, acute treatment, and stroke severity between employed and unemployed patients with acute ischemic stroke participating in ReNACer.