\n\nRESULTS: Twelve months postoperatively, 20 (96%) of the 21 eyes studied were within +/- 0.50 diopter (D) of the intended refractive outcome and 17 (81%) were within +/- 0.25 D. One eye

had a 0.325 D change in mean refractive spherical equivalent (MRSE). The change in MRSE in the other 20 eyes was less than 0.250 D between 1 month after lock-in and the 3-, 6-, and 12-month postoperative visits.\n\nCONCLUSIONS: The light-adjustable IOL reduced postoperative spherical and cylindrical errors of up to 2.00 D. Postoperative refractive errors were successfully corrected, and there was a significant improvement in UDVA with concomitant maintenance of CDVA. The achieved refractive check details change was stable after the adjustment and lock-in procedures.”
“A best evidence topic was written according to a structured protocol. Lack of evidence TH-302 exists regarding the optimal timing for coronary artery bypass graft (CABG) surgery after non-ST myocardial infarction (NSTEMI). While some authors address the importance of the timing

of surgery alone, others take into account the extent of myocardial damage. The question addressed was whether early or late CABG surgery improves hospital mortality and cardiovascular events after NSTEMI in stable patients. Using a designated search strategy, 459 articles were found, of which seven represented the best available evidence. All of these studies were level 3 (retrospective cohort studies). Studies could be divided into those which assessed CABG outcome based on preoperative cardiac troponin I (cTnI) level as a measure of the extent of myocardial damage and those which considered selleck inhibitor only the timing after myocardial infarction. Outcome measures included short-term survival, hospital mortality, length of hospital stay and major adverse cardiovascular events (MACEs). The biggest retrospective study analysing postoperative

outcomes based on the timing of surgery after NSTEMI concluded that operative mortality is higher when surgery is performed within 6 h of the event. After 6 h, mortality is similar at any timepoint after 6h of NSTEMI. While other smaller studies agree that there are fewer postoperative complications when surgery is performed after 48 h of the event, no consensus is found regarding mortality between early (less than 48 h) and late CABG surgery. Taking into account preoperative cTnI values, CABG has a higher incidence of MACEs and hospital mortality in patients with cTnI > 0.15 ng/ml. When surgery is performed within 24 h of symptoms, preoperative cTnI > 0.72 ng/ml is associated with worse outcomes.