Results of HSP90 and HSP70
immunoassays also showed gender specific related changes as both HSP families were unchanged in liver and muscle of male medaka but significantly increased in liver and muscle of female medaka, following PBDE-47 exposure. The gender specific effects of PBDE-47 on HSP expression profiles could not be explained by inherent differences in the heat shock response of male and female marine medaka, as the HSP profiles in liver and muscle, induced by acute heat shock, were similar in both sexes. The findings from this study provide evidence that PBDE-47 can cause gender specific modulatory effects on mechanisms critical to the apoptotic Belnacasan cascade as well as HSP regulation and expression. (C) 2014 Elsevier B.V. All rights reserved.”
“We aim to assess the correlation between audiometric data, and psychotic and acoustic measures associated with subjective tinnitus (ST) and to clarify the importance
of the psychological process in determining the degree of subjective annoyance and disability due to tinnitus. Fifty-four patients experiencing unilateral ST were allocated for the study. Acoustic assessment of patients including LDL (loudness discomfort Etomoxir chemical structure levels), MML (minimum masking level) and RI (residual inhibition) was performed. Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI) and Visual Analog Scale (VAS) tests were performed for the psychological aspects of subjective annoyance. RI was positive in 23 patients with 13 frequency-matched stimuli at 8,000 Hz. Masking treatment response was successful in 16 RI-positive patients. Mean and standard deviation (SD) of THI scores were 38.77 +/- A 23.63. Ten patients (%18.51) with tinnitus had a parts per thousand yen17 points score, which FRAX597 order was significant for BDI. Mean and SD were 5.01 +/- A 2.31 for VAS-1 scores (severity of tinnitus), 7.98 +/- A 2.79 for VAS-2 (frequency and duration of tinnitus), 5.77 +/- A 2.72 for VAS-3 (discomfort level), 3.56 +/- A 3.30 for VAS-4 (attention
deficit) and 3.31 +/- A 3.31 for VAS-5 (sleep disorders). A significant correlation was found between the tinnitus duration time, age, gender and THI scores (P < 0.05). There were statistically significant correlations between VAS 1, 2, 3 scores and LDL, MML and RI (P > 0.05). RI might be largely frequency dependent and was found as an indicator for the masking treatment response. We did not notice statistically significant correlations between audiometric data and THI and BDI. There were correlations between with VAS and LDL and with MML and RI. VAS was simpler and easier for the assessment of ST. We should consider the psychological aspects of ST and assess it as a symptom separately with acoustic and psychotic tests.”
“Response surface methodology was used to evaluate optimal time, temperature and oxalic acid concentration for simultaneous saccharification and fermentation (SSF) of corncob particles by Pichia stipitis CBS 6054.