Presents significant effects directly of the 24-hr deprivation period on the Minnesota Smoking Withdrawal and Wisconsin Smoking Withdrawal Scales. Significant increases in mean subject-rated withdrawal effects were found on both measures. *p < .05, ** ... The effects of 24-hr deprivation on RIP and DSST task performance varied as a function of sensation-seeking status. Significant sensation seeking �� session interactions were observed on RIP proportion correct, F(1,18) = 6.904, p < .05, and correct commissions, F(1,18) = 9.669, p < .05, and DSST incorrect responses, F(1,18) = 6.891, p < .05. Simple effects indicated that deprivation-induced impairment occurred only among high sensation seekers. Deprivation-induced increases were also seen on errors during the acquisition phase of the RA task (p < .

01) and correct responses on the performance phase of the RA task, but these effects did not differ as a function of sensation-seeking status. The effects of 24-hr deprivation on systolic blood pressure also varied as a function of sensation-seeking status. Follow-up testing indicated that systolic pressure decreased following deprivation for high sensation seekers, only (p < .05). Deprivation also decreased cardiovascular measures of heart rate and diastolic blood pressure, but these effects were not different among low and high sensation seekers. Smoking Effects Subjective Measures Minnesota Smoking Withdrawal Scale. Effects of nicotine yield on ratings of restlessness from 24-hr deprivation baseline level varied as a function of sensation-seeking status (Table 2, Figure 2, Panel A).

Simple effects analyses of the interaction indicated that decreases in ratings occurred as a function of nicotine yield in low sensation seekers alone, while high sensation seekers reported lower ratings of restlessness than low sensation seekers after smoking the 0.05-mg cigarette (i.e., changes in ratings among high sensation seekers occurred following smoking, regardless of nicotine yield; while changes among low sensation seekers were dependent on nicotine yield). Figure 2. Presents subject-rated effects of Minnesota Smoking Withdrawal Scale Restlessness (Panel A), Visual Analog Scale Stimulated (Panel B), and Profile of Mood States Elation (Panel C) during ad libitum smoking baseline and following 24 hr of deprivation prior … Nicotine reduced ratings on other MNWS similarly among low and high sensation seekers. Ratings on the MNWS Craving scale, pooled for sensation-seeking status, are presented in Panel A of Figure 3. Ratings were significantly lower after smoking Cilengitide the 0.6- and 0.9-mg cigarettes when compared with ratings following the 0.05-mg cigarette. Similar effects were observed on the other MNWS. Figure 3.