Most of the NIBP meters use oscillometry, automatic auscultation, or both [5].The low accuracy of the available automatic NIBP meters can be deduced from the standards imposed by the Association for the Advancement of Medical Instrumentation [10], the protocol designed by the British Hypertension Society (BHS) [1] and the recommendations of the European Society of Hypertension (ESH) [11]. The standards are based on comparing the automated NIBP meter to manual SPM for three examinations performed on each member of a group of 85 or 33 subjects. [1,10�C12]. The AAMI standard requires that the mean difference between the SBP (or DBP) values measured by the auscultatory SPM and the device under examination should not exceed 5 mmHg, and the standard deviation of that difference should not exceed 8 mmHg.

According to these standards, a device is acceptable even if 5% of its examinations differ from those of the reference device by 16 mmHg or more. The recommendations of the BHS and ESH are similar. The reason for not demanding higher accuracy seems to be the low accuracy of the available devices that are generally based on the oscillometry method.Nevertheless several recent Editorial Commentaries in Hypertension [13�C15] emphasize the added value of home blood pressure measurements and ambulatory blood pressure monitoring. Increasing evidence indicates that information about blood pressure variability obtained by monitoring provides prognostic information regarding organ damage and cardiovascular events beyond that derived from the average blood pressure value, obtained in office measurements [14,15].

Some studies even show better prediction of cardiovascular events by single home blood pressure measurements than by office measurements [13].1.2. SBP MeasurementSeveral techniques have been developed for the measurement of SBP by using the collapse of the artery under the cuff when the cuff pressure is above the SBP value. The reopening of the artery Cilengitide when the cuff pressure decreases below the SBP value can be detected by a distal flow or pulse detector, such as manual palpation, Doppler ultrasound, photoplethysmography (PPG) or strain gauge [16�C25]. Each of these techniques uses the detection of a flow-related signal which starts to reappear when the cuff pressure decreases below the SBP value, and the arteries under the cuff reopen for a short time during the cardiac cycle. In contrast to oscillometry, these techniques (like the auscultatory SPM which is based on the detection of Korotkoff sounds), enable the measurement of SBP with no need for an empirical formula, that must be based on statistical grounds.