Methods: Patients between the ages of sixty and eighty-five years were prospectively randomized to receive a cruciate-substituting rotating-platform design or a fixed-bearing design with an all-polyethylene tibial
component. There were no significant differences in the demographic characteristics (mean age, 72.2 years; mean American Society of Anesthesiologists score, 2.7; Smoothened Agonist mean body mass index, 31.8 kg/m(2)) or preoperative clinical or radiographic measures between the groups. Routine clinical and radiographic follow-up measures included the Knee Society score (KSS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Short Form-36 (SF-36) outcome measures.
Results: The results of 312 arthroplasties (136 with an all-polyethylene tibial component and 176 rotating-platform designs) in 273 patients were analyzed at a minimum of two years (mean, forty-two months) postoperatively.
Although there was significant improvement in both groups, there was no significant difference between the groups with regard to the mean postoperative range of motion (110.9 degrees and 109.1 degrees, respectively; p = 0.21), the mean KSS clinical score (90.4 and 88.2 points; p = 0.168), or the mean KSS pain score (44.9 and 43.1 points; p = 0.108) at this follow-up point. There were ten Fer-1 revisions: seven because of infection, one because of patellar fracture, one because of instability, and one because of aseptic loosening.
Conclusions: The two designs functioned equivalently at the time of early follow-up in this low-to-moderate-demand patient group. The rotating-platform design had no significant clinical advantage over the design with the all-polyethylene tibial
component.”
“Diospyros peregrina is an edible seasonal fruit found in coastal West Bengal, India. The fruits have been reported to possess a significant antioxidant activity. In this study, the aim was to isolate the lead compound responsible for the above-mentioned activity. The aqueous www.selleckchem.com/products/GSK461364.html extract of D. peregrina fruit was subjected to dereplication coupled with an in vitro 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. The n-butanol fraction of the aqueous extract of D. peregrina fruit exhibited significant antioxidant activity (IC50, 131.10 mu g mL(-1)) as compared with the parent extract (IC50, 285.15 mg mL(-1)). The n-butanol fraction was subjected to silica gel column chromatographic separation coupled with a chemo-autographic study of column eluents, employing ethanolic DPPH as a spraying reagent. Two bioactive flavonoid glycosides, namely luteoline-4′-methyl-ether-7-O-glucoside and quercetin-3-O-(glucosyl)- glucoside, were identified to exhibit IC50 values of 74.04 and 65.78 mu g mL(-1), respectively in the DPPH assay.”
“To understand the relative histopathological effects of PEEK particulate debris when applied within the epidural versus the intervertebral disc space.