isolates (%) range of the MICs +MIC50 +MIC90 S SDD R AMB All species (65) ≤ 0.007 – 1 0.06 0.12 65 (100) – Candida albicans (21) ≤ 0.007 – 0.5 0.06 0.12 21 (100) – Candida parapsilosis (19) 0.015 – 0.5 0.03 0.12 19 (100) – Candida tropicalis (14) 0.015 – 1 0.06 0.25 14 (100) – Candida glabrata (2) 0.015–0.5 0.12 0.25 2 (100) – Candida krusei (1) 0.25 – 0.5 0.25 0.5 1 (100) – Candida lusitaneae (1) 0.06 – 0.12 0.06 0.12
1 (100) – Candida guilliermondii (3) 0.015 – 1 0.015 0.06 3 (100) – Candida zeylanoides (1) 0.06 – 0.12 0.06 0.12 1 (100) – Candida rugosa Erismodegib cell line (1) 0.03 – 0.12 0.03 0.12 1 (100) – Candida dubliniensis (1) 0.12 – 0.25 0.12 0.25 1 (100) – Candida lipolytica (1) 0.12 – 0.25 0.12
0.25 1 (100) – FLC All species (65) ≤ 0.25 – > 128* 0.5 1 60 (92.31) 2 (3.07) 3 (4.62) Candida albicans (21) ≤ 0.25 – > 128* 0.25 4 21 (100) Candida parapsilosis (19) ≤ 0.25 – > 128* 0.5 0.5 19 (100) Candida tropicalis (14) ≤ 0.25 – > 128* 0.5 4.5 12 (85.71) 2 (14.29) Candida glabrata (2) ≤ 0.25 – > 128* 4 64 2 (100) Candida krusei (1) 16 – > 128 16 > 128 1 (100) Candida lusitaneae (1) 0.5 – 1 0.5 1 1 (100) Candida guilliermondii (3) 0.12 – 16 4 4 2 (66.67) 1 (33.33) Candida zeylanoides (1) 4 – 16 4 16 1 (100) Candida rugosa (1) 0.5 0.5 0.5 1 (100) Candida dubliniensis (1) ≤ 0.25 – 0.5 ≤ 0.25 0.5 1 (100) Candida NSC23766 lipolytica (1) 0.5
– 1 0.5 1 1 (100) ITC All species (65) ≤ 0.03 – > 16** ≤ 0.03 0.12 49 (75.38) 10 (15.38) 6 (9.23) Candida albicans (21) ≤ 0.03 – > 16** ≤ 0.03 ≤ 0.03 17 (80.95) 3 (14.28) 1 (4.76) Candida parapsilosis (19) ≤ 0.03 – > 16** ≤ 0.03 ≤ 0.03 18 (94.74) 1 (5.26) Candida tropicalis (14) ≤ 0.03 – > 16** ≤ 0.03 1.25 9 (64.28) 2 (14.28) 3 (21.43) Candida glabrata (2) ≤ 0.03 – 4 0.5 2 1 (50) 1 (50) Candida krusei (1) 0.12 – 2 0.5 2 1 (100) Candida lusitaneae (1) Tangeritin ≤ 0.03 – 0.12 ≤ 0.03 0.12 1 (100) Candida guilliermondii (3) 0.06 – 0.5 0.12 0.25 1 (33.33) 2 (66.66) Candida zeylanoides (1) 0.06 – 0.12 0.06 0.12 1 (100) Candida rugosa (1) ≤ 0.03 ≤ 0.03 ≤ 0.03 1 (100) Candida dubliniensis (1) 0.06 – 0.12 0.06 0.12 1 (100) Candida lipolytica (1) 0.25 – 0.5 0.25 0.5 1 (100) -Not determinate; +MIC results are medians; *Trailing effect to FLC [C. tropicalis (4), C. parapsilosis (3) and one C. glabrata(1)]; **Trailing effect to ITC [C. When the MIC Sotrastaurin order values for 24-SMTI (AZA and EIL) were analysed, we observed important antifungal activity for almost all Candida spp.