In all patients, pulmonary symptoms resolved after cessation of the drug. Pulmonary hypertension is another adverse effect of IFN therapy in HCV-infected patients and has been repeatedly reported by different authors. Dhillon et al.45 reported 4 cases of irreversible pulmonary hypertension that developed after IFN therapy in HCV-infected patients. One of the patients was a 35-year-old male liver transplant recipient who developed pulmonary hypertension Inhibitors,research,lifescience,medical after IFN therapy for HCV and died about 2.5 years later, with no response to treatments. The second was a 40-year-old female

HCV-infected individual who developed pulmonary hypertension 32 months after IFN therapy. Although the treatments failed to reverse her hypertension, she Inhibitors,research,lifescience,medical was stabilized. The third NLG919 research buy patient was a 50-year-old male liver transplant recipient who developed pulmonary hypertension after 10 months of IFN therapy. Although his hypertension did not respond to therapy, his clinical condition stabilized. The fourth patient was a 49-year-old male HCV-infected person who developed pulmonary hypertension 8 months after IFN initiation. The therapy was Inhibitors,research,lifescience,medical not successful in treating the hypertension, however the patient was

stabilized. Ischemia in the Gastrointestinal Tract Ischemia in the gastrointestinal tract is another peripheral vascular Inhibitors,research,lifescience,medical disorder associated with IFN therapy in HCV-infected patients.52 Leung et al.53 have reported an interesting case of ischemic colitis that developed 34 weeks after PEG-IFN-alpha; the patient’s symptoms rapidly resolved with the cessation of therapy. Similar observations were reported by Tada et al.,54 who presented 2 cases of IFN-alpha-induced ischemic colitis that developed 2 and 6 months after IFN administration. Both cases had complete resolution two weeks after cessation of IFN therapy. A recent case report by Baik et al.55 showed the development of ischemic colitis 19 weeks after the commencement of PEG-IFN-alpha-2a and Ribavirin

therapy; the case was thoroughly cured only with Inhibitors,research,lifescience,medical cessation of the drug. However, not all cases of ischemia in the gastrointestinal tract had benign courses. Pompili et al.56 introduced a 53-year-old male with HCV infection who medroxyprogesterone developed jejunal ischemia 3 months after the initiation of therapy with PEG-IFN. Although the patient underwent emergent jejuna resection, he died 6 months after surgery due to preoperative complications. A case of phlegmonous colitis that developed in a chronic HCV-infected patient who received combined therapy of PEG-IFN and Ribavirin also had a lethal consequence.57 A case of neutropenic enterocolitis that developed 22 weeks after the initiation of PEG-IFN-alpha-2a and Ribavirin had a fatal outcome.58 Other Systemic Complications Induced by Interferon (IFN) Therapy Wang et al.