002), 27 (p = 0.001), and 48 (p = 0.003) (Table 3). For fat-free mass, there was no significant difference between groups (p = 0.137). However, a significant difference was observed among the four testing sessions indicating that fat-free mass significantly

increased Selleck KU55933 at days 6 (p = 0.001), 27 (p = 0.001), and 48 (p = 0.001). There was also a significant increase at day 48 compared to days 6 (p = 0.012) and 27 (p = 0.022) (Table 3). There was no significant difference between groups for thigh muscle mass (p = 0.236); however, a significant difference was observed among the four testing sessions which revealed thigh muscle mass to be significantly increased at days 27 (p = 0.017) and 48 (p = 0.016). Increases were also seen at day 27 (p = 0.012) and 48 (p = 0.041) compared to day 6 (Table 3). Table 3 Body Composition Variables Variables Day 0 Day 6 Day 27 Day 48 Body Weight (kg)   * (p = 0.015) * (p = 0.006) * (p = 0.027) PLA 77.91 (18.36) 77.94 (17.76) 78.52 (18.64) Ilomastat supplier 78.80 (18.50) CRT 89.42 (22.08) 90.76 (22.60) 90.55 (22.54) 90.09 (22.86) CEE 73.69 (14.94) 74.49 (14.48) 74.91 (15.19) 75.32 (15.21) Fat-Free Mass (kg)   * (p = 0.001) * (p = 0.001) * (p = 0.001) PLA

54.55 (10.05) 55.10 (9.60) 56.05 (10.19) 56.25 (10.22) CRT 63.27 (10.79) 64.68 (11.18) 65.54 (11.68) 65.12 (11.39) CEE 59.06 (8.46) 59.74 (8.16) 60.01 (8.52) 60.11 (8.11) Fat Mass (kg)   * (p = 0.002) * (p = 0.001) * (p = 0.003) PLA 14.34 (8.92) 13.80 (8.65) 13.66 (8.89) 13.68 (8.94) CRT 21.55 (12.63) 21.09 (12.40) 20.20 (12.06) 20.08 (12.15) CEE † (p = 0.043) 10.44 (7.28)

10.41 Calpain (7.49) 10.50 (7.59) 10.88 (7.88) Thigh Mass (kg)     * (p = 0.017) * (p = 0.016) PLA 8.07 (1.77) 8.17 (1.73) 8.31 (1.73) 8.36 (1.71) CRT 8.93 (1.78) 9.17 (1.79) 9.28 (1.84) 9.34 (1.93) CEE 7.58 (.81) 8.06 (1.35) 8.22 (1.31) 8.21 (1.36) Data are expressed as mean (± SD). * indicates a significant difference at the respective testing session. † indicates a significant difference between groups (p < 0.05). Body water There was no significant difference between groups for total body water (p = 0.276). However, a significant difference existed among the four testing sessions indicating that total body water was significantly increased at days 27 (p = 0.022) and 48 (p = 0.001). There was also a significant increase at day 48 compared to day 6 (p = 0.002) (Table 4). No significant difference between groups existed for intracellular body water (p = 0.198). A significant difference was observed among the four testing sessions indicating there to be increases in intracellular body water at days 27 (p = 0.023) and 48 (p = 0.001).