Continuous variables were expressed as median (interquartile range) and data compared with Mann–Whitney U-test. Categorical variables were expressed as percentages and data compared using χ2-test. A P < 0.05 was considered statistically significant. Variables with a P-value of less than 0.20 in the univariate analysis and with clinical relevance were subsequently introduced to a multiple linear regression model to modulate the behavior of the dependent variable (quality of life). A multivariate analysis

was performed to confirm that the relationship found between HRQL and associated variables (MHE and appetite) remains besides the differences observed among both groups of patients Dabrafenib clinical trial (with and without MHE) at baseline. Two models of multiple linear regressions were

performed. The first model included the laboratory and clinical components of the Child–Pugh score, whereas the second model included the Child–Pugh score. The aim was to analyze if both models had the same effect on HRQL. The independent variables were eliminated and reconsidered from the analysis if the P-value was greater than 0.05. This procedure was developed step-by-step until no variable could be included or removed according to the above criteria. All data were analyzed using SPSS version 19 (SPSS, Kinase Inhibitor Library manufacturer Chicago, IL, USA). One hundred and twenty-five patients with a diagnosis of decompensated hepatic cirrhosis were selected, of whom 55 (44.0%) presented MHE. The median age of the patients with MHE and without MHE was 59 and 53 years, respectively. When comparing clinical and demographic characteristics of both groups, significant differences were observed in age, 上海皓元医药股份有限公司 Child–Pugh index, leukocytes, platelets, creatinine, hematocrits, albumin and prothrombin time (Table 1). Forty-one patients (58.6%) without MHE had moderate malnutrition, similar to the group with MHE (n = 31, 56.4%). When appetite was evaluated by VeAS (Table 2), 21.8% of the patients with MHE endorsed having little appetite and 23.6%

endorsed having good appetite, compared with 11.4% and 37.1%, respectively, in patients without MHE (P = 0.108). When comparing the medians obtained with the ViAS, a reduction in appetite was observed in patients with MHE, although this difference was not statistically significant. Nevertheless, upon stratifying the patients according to the Child–Pugh score, among those with MHE a reduction in appetite was observed as the degree of hepatic damage increased (Child A 5.6 [5.1] vs Child B 4.5 [2.2] vs Child C 4.4 [3.2]; P = 0.074), a situation that was not present in patients without MHE (Child A 4.8 [1.5] vs Child B 4.6 [2.1] vs Child C 6.1 [3.3]). In the MHE group, a significant reduction was observed in appetite (P = 0.027) in patients with Child B compared with those classified as Child A. Table 3 shows the medians of the six domains and the overall score of the CLDQ.