cdc.gov/genomics/hugenet). The electronic databases of the China National Knowledge Infrastructure and MEDLINE were searched for all case-control or cohort studies that evaluated SLCO1B1 in association with neonatal hyperbilirubinemia between January of 1980 and December of 2012, using the following search strategy: (Hyperbilirubinemia, Cilengitide Neonatal OR (Bilirubin AND Infant, Newborn) OR Jaundice, Neonatal) AND (Organic Anion Transporters OR Polymorphism, Restriction Fragment Length OR SLCO1B1 protein, Organic Anion Transport Polypeptide

C OR Genetic Predisposition to Disease OR Polymorphism). The MEDLINE database was searched using the following search strategy: (Hyperbilirubinemia, Neonatal OR (Bilirubin AND Infant, Newborn) OR Jaundice, Neonatal) AND (Organic Anion Transporters OR Polymorphism, Restriction Fragment Length OR SLCO1B1 protein, human OR DNA Mutational Analysis OR Gene Frequency OR Genotype OR Mutation OR Organic Anion Transport Polypeptide C OR Genetic Predisposition to Disease OR Polymorphism, Genetic OR DNA OR Polymorphism, Single Nucleotide). No language restrictions were applied. Polymorphisms PD0325901 in vitro related to neonatal hyperbilirubinemia were divided into three groups according to the three variants (388

G>A, 521 T>C, and 463 C>A) of SLCO1B1. Case-control, cohort, and family-based studies presenting original data on associations between the genetic polymorphisms and neonatal hyperbilirubinemia were eligible for inclusion, provided that (i) the cases of neonatal hyperbilirubinemia Methamphetamine were included according to the diagnostic criteria utilized in various countries; (ii) the control group consisted of comparable infants without a history of hyperbilirubinemia; (iii) the enrollment of participants was made based on prior knowledge of genotype, and genotyping; (iv) the study reported the ethnic ancestry of participants; and (v) the reported genotype distributions were in Hardy-Weinberg equilibrium. Hardy-Weinberg equilibrium was performed by chi-squared analysis. Exclusion criteria included review articles as well as articles that studied populations aged up to 28 days. Two investigators (Long J and

Zhang SF) extracted data independently. When conflicting evaluations occurred, an agreement was reached after a discussion. Briefly, for all studies, the following data were extracted from the original publications: first author and year of publication; genes and relevant polymorphisms; neonatal hyperbilirubinemia definition; study population; number of genotyped cases and controls; frequencies of genotype; and SLCO1B1 gene polymorphism genotyping information. Stata software (version 9.0; Stata Corp. LP – College Station, TX, USA) was used to pool data from case–control or cohort studies. These studies mainly provided three genotypes, and these genotype groups were assessed using allelic comparisons and mutant comparisons (heterozygous and homozygous mutant type vs. homozygous wild type).