Based on our findings, we suggest that ApoG2 induced cell cycle arrest is dependent on ApoG2s downregulation of c Myc expression. Use of ApoG2 to treat NPC may sup press the activity of estrogen and progesterone and reduce the incidence of distant metastasis and local relapse. The concept of targeted biological therapy for cancer has emerged over the past decade. Clinical trials studying the twice efficacy and tolerability of these targeted agents has shown that most tumors depend on more than one sign aling pathway for their growth and survival. Therefore, investigators pursue different strategies to inhibit multiple signaling pathways by developing multitargeted agents. The recent U. S.
Food and Drug Administration approval of sorafenib and sunitinib, which target vascular endothelial growth factor receptor, platelet derived growth factor receptor, FLT 3, and c Kit, marks the use of a new generation of multitarget anticancer drugs. Our study show that ApoG2 is one such multitarget agent that targets Inhibitors,Modulators,Libraries both the antiapoptotic and cell cycle progression pathway in NPC cells by blocking antiapoptotic Bcl 2 pro teins and the c Myc oncogenic pathway. These findings provide an entirely new concept for the use of ApoG2 in cancer therapy. Conclusion Our findings indicated that ApoG2 can potently disturb the proliferation of NPC cells by suppressed c Myc signal ing pathway. This data suggested that the inhibitory effect of ApoG2 on NPC cell cycle proliferation might contrib ute to its use in anticancer therapy.
Inhibitors,Modulators,Libraries Background Tuberous Sclerosis Complex is an autosomal dominant tumor disorder characterized by the manifes tation of hamartomas in various organs including the kidney, brain, skin, lungs, and heart. This multi system disorder is fairly common, occurring at a fre quency of 1 6000. The morbidity associated with TSC includes cognitive impairment, seizures, epilepsy, corti cal tubers, cardiac rhabdomyomas, facial angiofibromas, and pulmonary lymphangioleiomyomatosis. Additionally, a majority of TSC patients experience renal manifestations such as kidney angiomyolipomas and or kidney cysts. Kidney angiomyolipomas are age related tumors that occur in 60 80% of older children and adults with TSC and approximately 50% of women with sporadic LAM. Sporadic LAM is a pro gressive pulmonary disorder that is genetically related to TSC in that somatic mutations in the TSC1 or TSC2 genes have been identified in abnormal lung tissues from LAM patients.
TSC results from the Inhibitors,Modulators,Libraries loss of function of one of two genes, TSC1 or TSC2, whose gene products are hamar tin and tuberin, respectively. These two gene pro ducts form a tumor suppressor complex that functions Inhibitors,Modulators,Libraries to inhibit mTOR activity in a conserved cellular signal ing pathway which is responsible for cell proliferation, protein synthesis, and nutrient uptake. The key proteins in this pathway include PI3K, Akt, TSC1 Inhibitors,Modulators,Libraries Belinostat TSC2, Rheb, and mTOR.