As seen in Figure 4, the grand averaged P100 waveforms (mean latency 118 ± 4 msec) for the remaining three conditions (SIM, TVd, TT) displayed a bilateral distribution at parietal sites and maximal amplitude at electrode site PZ. Results showed a main effect of condition observed at electrode

sites P4 (F2,28 = 7.95, P = 0.002), PZ (F2,28 = 5.97, P = 0.007), and P3 (F2,28 = 10.73, P < 0.001). Tukey's post hoc tests showed that for each electrode site, the amplitude of the P100 was larger in the SIM compared to the TVd task (P < 0.05) and the TT task (P < 0.05, Fig. 5B). A main effect of condition was found for the P100 latency Inhibitors,research,lifescience,medical at electrode P4 using separate one-way repeated measures ANOVA (F2,28 = 3.64, P = 0.04). However, Tukey's post hoc analysis revealed no statistically significant differences between conditions. Furthermore, no main effect

of condition was found for electrodes PZ (F2,28 = 1.02, P = 0.37) Inhibitors,research,lifescience,medical or P3 (F2,28 = 0.36, P = 0.7). Tyrphostin AG-1478 solubility dmso Figure 4 Grand averaged P100 waveforms. Grand average P100 waveforms are shown for parietal electrode Inhibitors,research,lifescience,medical sites (P3, PZ, P4) for SIM, TVd, and TT conditions. The P100 ERP component is labeled on the trace for electrode site P3. Gray, red, and black traces show SIM, … Behavioral data Figure 6 shows the behavioral means and standard error bars for each task-relevant crossmodal condition: SIM (mean = 92, SE = 3.3), VTd (mean = 83, SE = 2.9), TVd (mean = 98, SE = 3.4). A one-way repeated measures ANOVA was performed on the error differences represented as a percent score across all conditions and showed that there was a main effect of condition (F2,16 = 8.45, P = 0.003). Inhibitors,research,lifescience,medical Post hoc Tukey’s test showed that performance in the VTd condition was significantly different than the TVd task. Participants tended to produce lesser force than the ideal target in the VTd condition. There were no other

differences between conditions. Figure 6 Group means for behavioral data. The gray bar graph represents group data for the visual + tactile simultaneous condition (SIM), the red bar graph represents group data for the condition where tactile stimuli were Inhibitors,research,lifescience,medical presented 100 msec … Discussion In this study, we used EEG and crossmodal stimuli (visual + vibrotactile) to examine the roles of visual information and attentional relevance in modulating early cortical responses generated in SI. To test the influence of bottom-up sensory-sensory interactions Histone demethylase and top-down attentional processes on early modality-specific cortical responses, we devised a novel experimental protocol that manipulated the temporal onsets of task-relevant crossmodal (visual + tactile) interactions. In one condition, visual stimuli preceded the onset of tactile stimuli by 100 msec (i.e., VTd), in order to observe the influence of the visual modality on the P50 component generated in SI. In another condition, tactile stimuli preceded the onset of visual stimuli by 100 msec (i.e.