CASE: A 35-year-old woman experienced cyclic premenstrual urticaria and angioedema occurring from 4 days before to 5 days after menses. The diagnosis of progesterone autoimmune dermatitis was made by a progesterone-positive skin test. Autologous serum skin test, using sera from estrogenic and luteal phases, also elicited a positive response. The patient became pregnant with near-clearance of the urticaria.
CONCLUSION: https://www.selleckchem.com/products/cbl0137-cbl-0137.html Skin tests with progesterone and autologous serum, which are easy to perform, convenient, and inexpensive, are highly useful for establishing the diagnosis of progesterone autoimmune dermatitis and ruling out other skin disorders. (Obstet
Gynecol 2011;117:495-8) DOI: 10.1097/AOG.0b013e318206cb2c”
“Purpose Selleck GSK 872 of review To
survey genetic variation contributing to variable responsiveness and toxicity to important cardiovascular drugs and highlight recent developments in the field of cardiovascular pharmacogenomics and personalized medicine.
Recent findings Previously recognized pharmacogenomic associations with drug efficacy have been further validated (e.g. with clopidogrel and warfarin) and shown to influence clinically important outcomes. The clinical significance of variants modulating toxicity (e.g. SLCO1B1 with simvastatin) has also been confirmed. The genetic contribution to variable efficacy and toxicity of other important classes of cardiovascular drugs, such as beta blockers, is becoming increasingly recognized. Prospective trials testing whether the use of genomic information improves clinical care are underway. Guidance based on the most well-established see more pharmacogenomic findings has appeared in prescribing labeling and is in the early stages of being implemented into routine clinical care.
Summary Clinically
validated gene variants that modulate responsiveness to cardiovascular drugs continue to be discovered and validated. Early steps are underway to translate these discoveries into clinical care.”
“Background: The objective of this study was to determine the role of plasma oxygen carrying capacity during resuscitation from hemorrhagic shock (HS).
Methods: Hemodynamic responses to small-volume resuscitation from HS with hypertonic saline followed by infusion of ultrahigh-molecular-weight tense-state polymerized hemoglobins (PolyHbs) were studied in the hamster window chamber model. HS was induced by withdrawing 50% of the blood volume (BV), and hypovolemic state was maintained for 1 hour. Resuscitation was implemented by infusion of hypertonic saline (3.5% of BV) followed by 10% of BV infusion of polymerized human Hb (PolyHb(hum), P(50) = 49 mm Hg), polymerized bovine Hb (PolyHb(bov), P(50) = 40 mm Hg), or human serum albumin (HSA), all at 10 g/dL. Resuscitation was monitored over 90 minutes.