Previous studies have neither classified nor considered as part of the selection criteria the degree of decompensation, so it is unknown if the frequency of MHE is lower in patients with compensated cirrhosis. Health-related quality of life in patients with MHE has been evaluated with various ICG-001 questionnaires and in various populations.[5, 7, 8, 13, 14, 32, 42, 43]

To date, results are not consistent in regards to the effect of this complication on the daily life of patients with cirrhosis. Based on the results of this study, MHE is a factor that deteriorates HRQL in patients with decompensated cirrhosis, showing significant difference in the domains of fatigue, systemic symptoms, emotional function, activity and overall score, independent of the scoring obtained in the Child–Pugh index. The multivariate analysis confirms that MHE is a complication that impaired the domains of activity, emotional function and global scoring on the CLDQ questionnaire. Perhaps one of

the main causes of inconsistent results in patients with MHE is the inclusion in the analysis of heterogeneous groups of patients. Up to now, this is the first article that includes only patients with decompensated cirrhosis, who have a greater risk of mortality and who develop different complications than patients with compensated cirrhosis.[18, 40, 41] Therefore, it is important to classify patients not only according to the Child–Pugh score, but also to the degree of decompensation. Besides Gefitinib the inclusion of patients with alcoholic cirrhosis in our study, the multivariate analysis shows that MHE is an independent factor that deteriorates HRQL. However, to confirm that the relationship between these two variables remains, we performed an analysis excluding patients with alcoholic cirrhosis and HRQL was significantly MCE lower in the domains of activity, emotional function, worry and overall score in patients with MHE compared with non-MHE patients (data no shown). It

is worth mentioning that not all previous studies have excluded patients with a history of OHE, which increases the frequency of MHE because some patients have persistent cognitive impairments after the treatment and resolution of OHE, which has a negative impact on HRQL of patients with liver cirrhosis.[13, 36] In addition, various questionnaires have been used to evaluate quality of life, both generic and specific, which makes results difficult to compare. The specific questionnaire for hepatic failure approaches aspects of the social environment, hepatic encephalopathy and fatigue which are not completely covered in general questionnaires, including SF-36.[44] Nonetheless, as has been reported in patients with MHE, there is a greater risk of causing or suffering car accidents as well as falls.