Gastrointestinal complaints (diarrhea/vomiting/dehydration) were also common (129, 55%); this was consistent across all age groups from May to August. An additional BI 6727 datasheet 13 children had febrile or afebrile seizures, three had encephalitis and one had aseptic meningitis. Hospital course of cases is shown in Table 2. While the overall median length of stay was 4 days (1–65); it was slightly lower for infants <6 months (2 days) and for healthy children (3 days). Intensive care was required for 39 children (17%), 15 of whom required assisted

ventilation. Antiviral use was reported in 107 (46%) children, including 8 (33%) of those under age 6 months. Oseltamivir was used almost exclusively (99%). Secondary bacterial infections were documented in 8 (3.4%) patients, 5 of whom were previously healthy. Invasive Streptococcus pneumoniae (n = 3) and Group A Streptococcus (n = 3) infections occurred most frequently, followed by Haemophilus influenzae Type F (n = 1), and Escherichia coli (n = 1). There were no Staphyloccocus aureus infections. The three children with invasive UMI-77 molecular weight pneumococcal disease were >1 year of age and had been age

appropriately immunized with 7-valent conjugate pneumococcal vaccine. Pneumococcal serotype information was not available. A total of 40 (17%) patients received 2008–2009 seasonal influenza vaccine, with 68% (27/40) of those having an underlying condition recommended for seasonal vaccination. In the 6–23-month age group (for whom vaccination is also recommended),

6% (3/49) had a reported seasonal influenza vaccination. Two deaths occurred during the first pandemic wave. A 6-year-old male with a seizure disorder, metabolic disorder and developmental delay, was admitted after 4 days of symptoms which included respiratory distress and diarrhea, vomiting, and dehydration. He received oseltamivir and antibiotics and required ventilation but died 3 days later. The second death occurred in a 7-year-old male with a seizure disorder, cerebral palsy and scoliosis who was admitted to hospital after a 4-day illness, with fever, cough and diarrhea, vomiting, and dehydration. He received antibiotics, Calpain but no antivirals and died 1 day after admission. This case series summarizes 235 pediatric cases of pandemic influenza hospitalized during the first wave of the pandemic in Canada. Understanding the epidemiological and clinical aspects of H1N1 disease and its similarities and differences to seasonal influenza is crucial for pandemic planners to allocate vaccine. Our data support other findings [14], [15] and [16] that show that infection with the novel pandemic strain is similar in severity to seasonal influenza. The majority of children under 2 years were previously healthy, while older children who were admitted were more likely to have underlying health conditions, similar to what is found with seasonal influenza [2], [3], [4], [5] and [6].