3% of the 605 men who underwent RP and 15% of the patients had a locally advanced tumor. Specimens of 26% of patients showed a nonsignificant PCa on pathologic examination. Challacombe and coworkers23 investigated the peri-operative morbidity, functional,

and oncological outcome of robotic-assisted radical prostatectomy (RARP) in 65 patients over age 70 years (mean age, 71.9 years). When Inhibitors,research,lifescience,medical compared with a younger group (mean age, 60.2 years), results were comparable and the authors concluded that RARP is a safe and effective treatment with good results in men over age 70 years. The formation of scar tissue at the vesico-urethral anastomotic site leading to anastomotic stricture is a potential complication

after RP. Hruza and coworkers24 presented their results on the incidence of anastomotic strictures in 2200 consecutive patients treated with laparoscopic radical prostatectomy Inhibitors,research,lifescience,medical (LRP). A total of 4.6% of the patients developed anastomotic stricture, almost all of them occurring within the first 3 years after surgery. Seven parameters were reported in this study to be risk factors of anastomotic stricture formation, namely, prolonged catheter time for anastomotic insufficiency (P < .001), intermittent suture for urethrovesical anastomosis (P = .001), surgeon (P = .029), operative time > 4 hours (P = .016), transperitoneal access (P = .041), nonnerve-sparing Inhibitors,research,lifescience,medical surgery (P = .014), and high body mass Inhibitors,research,lifescience,medical index (BMI) (P = .035). The overall anastomotic stricture rate after LRP was low, and a low BMI was the only patient-related parameter with a positive impact on anastomotic stricture rates. Metastatic Disease Androgen deprivation therapy remains a hot topic in the management of advanced PCa. In the Scandinavian

Prostate Cancer Group (SPCG)-5 study25 patients with newly diagnosed PCa were randomized to Inhibitors,research,lifescience,medical receive either total androgen blockade (TAB) or polyestradiol phosphate (PEP). No difference could be observed between the treatment groups in terms of biochemical (TAB 10.1 months vs PEP 10.2 months, P = .58) or clinical progression-free survival, or in overall (hazard ratio [HR] 0.96, confidence interval [CI], 0.82–1.12) or disease-specific survival (HR 0.9, CI, 0.77–1.08). In Barcelona, Brasso and colleagues26 presented an analysis of a subgroup of 131 patients, originally included Brefeldin_A into the SPCG-5 study, to evaluate the selleck prognostic impact of urokinase plasminogen activator receptor (uPAR) in patients with metastatic PCa. They were able to AZD9291 confirm that all 3 forms of uPAR measured in pretreatment serum samples held prognostic information. Highest uPAR levels were associated with shortest survival. In a multivariate analysis uPAR was shown to be an independent prognostic factor with regard to survival. Interestingly, a qualitative interaction between levels of uPAR and treatment modality with regard to survival could be observed.